Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion
Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion
批准号:
22791955
负责人:
ABE Masanobu
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
324 of highly methylated genes at promoter region were identified by MeDIP-CGI microarray assay in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2). Furthermore, the global expression levels between before and after 5-aza-dC treatment in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2) were analyzed and 351 of highly up-regulated genes by the treatment were identified. Finally, 125 of silencing genes by promoter methylation were identified in oral squamous cell carcinoma cell lines.
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会议论文
口腔前癌病変悪性化におけるエピジェネティクスを指標としたリスクマーカーのゲノム網羅的探索
基于表观遗传学的全基因组搜索口腔癌前病变恶变风险标记
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ono H, Ohtani N, Matoba A, Kido K, YasuiY, Masaki E., 阿部雅修]
通讯作者:
阿部雅修
DNAメチル化異常を指標とした口腔前癌病変悪性化のリスクマーカーの探索
以DNA甲基化异常为指标寻找口腔癌前病变恶变的风险标志物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[阿部雅修, 森良之, 西條英人, 杉山円, 高戸毅]
通讯作者:
高戸毅
海外基金