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Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion

Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion
阐明口腔癌前病变导致口腔恶性肿瘤的表观遗传异常
批准号:
22791955
负责人:
ABE Masanobu
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
324 of highly methylated genes at promoter region were identified by MeDIP-CGI microarray assay in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2). Furthermore, the global expression levels between before and after 5-aza-dC treatment in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2) were analyzed and 351 of highly up-regulated genes by the treatment were identified. Finally, 125 of silencing genes by promoter methylation were identified in oral squamous cell carcinoma cell lines.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ono H, Ohtani N, Matoba A, Kido K, YasuiY, Masaki E., 阿部雅修]
通讯作者: 阿部雅修
DNAメチル化異常を指標とした口腔前癌病変悪性化のリスクマーカーの探索
以DNA甲基化异常为指标寻找口腔癌前病变恶变的风险标志物
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [阿部雅修, 森良之, 西條英人, 杉山円, 高戸毅]
通讯作者: 高戸毅
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