A development of the comprehensive tooth regenerative therapy by the bioengineered tooth unit transplantation.

在目前的全牙再生治疗研究中，一个基本的策略是将生物工程牙胚诱导发育成功能齐全的牙齿。我们证明了一个生物工程牙齿单元，这是一个成熟的生物工程器官的模型，成功移植到体内缺失的牙齿区域，并随后通过这种移植恢复牙齿功能。我们还表明，这种移植可以恢复骨体积在垂直和水平尺寸在缺牙小鼠模型严重广泛的骨缺损。这些发现表明，通过生物工程成熟牙单元的移植，全牙再生治疗是可行的。这项研究还提供了通过移植生物工程成熟器官实现整个器官再生的第一个证据。

In current research on whole-tooth regenerative therapy, a basic strategy is being pursued in which a bioengineered tooth germ is induced to develop into a fully functional tooth. We demonstrate the successful transplantation of a bioengineered tooth unit, which is a model for a mature bioengineered organ, into a missing tooth region in vivo and the subsequent restoration of tooth function by this graft. We also show that this transplantation can restore the bone volume in both the vertical and horizontal dimensions in a missing tooth mouse model with a serious extensive bone defect. These findings indicate that whole tooth regenerative therapy is feasible through the transplantation of a bioengineered mature tooth unit. This study also provides the first reported evidence of entire organ regeneration through the transplantation of a bioengineered mature organ.