Availability of measurement of salivary alpha-amylase activity for evaluation of surgical stimuli and postoperative pain

测量唾液 α-淀粉酶活性以评估手术刺激和术后疼痛的可用性

• 批准号: 22792020
• 负责人: HIROSE Noriya
• 金额: $ 0.5万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792020/
• 关键词: 疼痛評価; 唾液アミラーゼ活性; 疾痛評価

In this study, salivary alpha-amylase activity(sAA) which indicate of sympathetic activity was significantly induced after tracheal intubation and skin incision under general anesthesia. In contrast, perioperative and postoperative sAA values did not associate with sAA, VAS(visual analogue scale) and analgesic agent usage during 48 hours after operation. These results suggest that measurement of sAA might be a method for evaluation of noxious stimuli under general anesthesia, however, it is probably difficult to assess postoperative pain.

在本研究中，在全麻下气管插管和皮肤切开后，显著诱导了反映交感神经活性的唾液α-淀粉酶活性（sAA）。相比之下，围手术期和术后sAA值与术后48小时内sAA、VAS（视觉模拟评分）和镇痛剂使用无关。这些结果表明，sAA的测量可能是一种方法来评估全身麻醉下的伤害性刺激，但它可能是难以评估术后疼痛。