Analysis of promoter of human BRAK/CXCL14, a tumor suppressor
Analysis of promoter of human BRAK/CXCL14, a tumor suppressor
批准号:
22792023
负责人:
KOMORI Reika
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
BRAK/CXCL14 is a chemokine that is absent from or expressed at very low levels in head and neck squamous cell carcinoma. We set to this gene as molecular target therapy. In order to study the regulatory mechanisms governing the expression of this gene, we determined the promoter motifs of the expression of this gene. The results of that, TATA-like sequence, TATTAA was essential for stimulating the expression of the gene and the AP-1 binding sequence and tandem GC Box3, 4 were necessary for stimulating the expression of the gene in human squamous epithelial cells.
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ケモカインBRAK/CXCL14の転写制御機構の解析
趋化因子BRAK/CXCL14转录调控机制分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小森令賀, 大久保孝一郎, 松澤光洋, 木本茂成]
通讯作者:
木本茂成
Oxidative stress reduce expression of CXCL14/BRAK in human cells.
氧化应激降低人类细胞中 CXCL14/BRAK 的表达。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[MAEHATA Y.,OZAWA S., MIYAMOTO C.,KOBAYASHI K.,KOMORI R.,HATA R.-I.,LEE M.C.-I.]
通讯作者:
MIYAMOTO C.,KOBAYASHI K.,KOMORI R.,HATA R.-I.,LEE M.C.-I.
Analysis of promoter region of human BRAK/CXCL14 in SCC cells.
SCC 细胞中人 BRAK/CXCL14 启动子区域的分析。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Komori, R., Ozawa, S., Kato, Y., Maehata, Y., Shinji, H., Hata, R.-I, Kimoto, S.]
通讯作者:
S.
DOI:
10.2220/biomedres.31.123
发表时间:
2010-04-01
期刊:
BIOMEDICAL RESEARCH-TOKYO
影响因子:
1.2
作者:
[Komori, Reika, Ozawa, Shigeyuki, Hata, Ryu-Ichiro]
通讯作者:
Hata, Ryu-Ichiro
海外基金