Morphological analysis of regeneration of periodontal ligament in newly developed clinical rat models

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We developed rat clinical study models of occlusal trauma and orthodontic tooth movement and demonstrated behavior of aquaporin positive periodontal ligament cells in the experimental models. In the occlusal trauma model, transitory aquaporin expression in the fibloblast-like cells was observed during the removal of the hyalinized tissue and the regeneration of the periodontal ligament. In the orthodontic tooth movement model, the aquaporin expression appeared to be temporarily increased on the membrane of the fibleblast-like cells with the activation of PDL cell motility. Our results suggest that aquaporin is involved in periodontal ligament cell motility during occlusal trauma and orthodontic tooth movements.