Possible Mechanisms of Progression of Periodontal Disease by TACE-Timp3 Interaction in Patients with Diabetes Mellitus

控制不佳的糖尿病患者的牙周病具有非常严重的炎症。在本研究中，高血糖增强了人牙龈成纤维细胞中TACE活性和MMP-3的产生。此外，重组活化的MMP-3增强了巨噬细胞样分化的THP-1中可溶性IL-6受体的脱落。这些结果表明，在血糖控制不佳的糖尿病患者中，高血糖诱导的TACE和MMP-3在牙龈成纤维细胞/巨噬细胞相互作用中的促进作用通过增强IL-6信号转导诱导严重的牙周炎症。

Periodontal disease in poor controlled-diabetic patients has very severe inflammation. In the present study, hyperglycemia enhanced TACE activity and MMP-3 production in human gingival fibroblasts. In addition, recombinant activated MMP-3 enhanced the shedding of soluble IL-6 receptor in macrophage-like differentiated THP-1. These results suggest that hyperglycemia-induced facilitation of TACE and MMP-3 in gingival fibroblasts/macrophage interaction induce severe periodontal inflammation through enhancement of IL-6 signaling in the patients with poor controlled-diabetic mellitus.