Effect of p53 on regeneration of periodontal tissue : Using small molecule compounds

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In this study, we investigated the effect of p53 on differentiation of periodontal ligament tissue using the small molecule compounds HLI98 and HLI373. HLI98 and HLI373 increased the expression of p53 in osteoblast. However, these compounds enhanced cell death when we performed long-term cell culture because of the toxicity of these compounds. Therefore, we utilized Bortezomib which inhibits degradation of p53 and stabilizes p53 expression. Bortezomib clearly induced p53 expression and calcification of periodontal ligament cell line MPDL-22. These data indicate that p53 enhances differentiation of periodontal ligament cell.