The elucidation of the onset mechanism of pressure ulcers which took notice of the blood permeability change by percutaneous pressure

为了阐明压疮的发病机制，我们在大鼠的活体实验中测量了氧分压，这是一个评估组织氧气供应的标准，以及随着压力的施加，组织摄氧量随时间的变化。重复施加和释放施加的压力；施加的压力的力在10、15和20 mm Hg之间改变，持续时间在3、5和8分钟之间改变。PO2随加压次数的增加而降低，随压力的释放而回升，且随着加压次数的增加，PO2波动更大。加压时间越长，释放压力后恢复PO2所需的时间越长。在改变压力应用直径的单独试验中，发现PO2的变化不仅与施加压力的力有关，而且还与施加压力的区域有关。

To elucidate the onset mechanism of pressure ulcers, we measured the oxygen partial pressure, a standard for assessing the supply of oxygen to tissues and the changes over time in oxygen uptake into tissue with the application of pressure in an in vivo experiment using rats. The applied pressure was repeatedly applied and released ; the force of the applied pressure was changed between 10, 15, and 20 mmHg and the duration was changed between 3, 5, and 8 minutes. PO2 decreased with the application of pressure and recovered with the release of pressure, and PO2 fluctuated more with an increase in the number of times pressure was applied. For longer pressure application times, more time was needed for recovery of PO2 after the release of pressure. In a separate trial of changing the diameter of the pressure application, it was found that changes in PO2 are related not only to the force of the applied pressure, but also to the area over which pressure is applied.