The elucidation of the onset mechanism of pressure ulcers which took notice of the blood permeability change by percutaneous pressure

关注经皮压力引起的血液渗透性变化，阐明压疮的发病机制

• 批准号: 22792135
• 负责人: MIKI Masahito
• 金额: $ 1.66万
• 依托单位: Saitama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792135/
• 关键词: 褥瘡; 血液透過性; 加圧

To elucidate the onset mechanism of pressure ulcers, we measured the oxygen partial pressure, a standard for assessing the supply of oxygen to tissues and the changes over time in oxygen uptake into tissue with the application of pressure in an in vivo experiment using rats. The applied pressure was repeatedly applied and released ; the force of the applied pressure was changed between 10, 15, and 20 mmHg and the duration was changed between 3, 5, and 8 minutes. PO2 decreased with the application of pressure and recovered with the release of pressure, and PO2 fluctuated more with an increase in the number of times pressure was applied. For longer pressure application times, more time was needed for recovery of PO2 after the release of pressure. In a separate trial of changing the diameter of the pressure application, it was found that changes in PO2 are related not only to the force of the applied pressure, but also to the area over which pressure is applied.

为了阐明压力性溃疡的发病机制，我们测量了氧分压，这是一个评估组织供氧的标准，并在大鼠体内实验中应用压力测量了组织氧摄取随时间的变化。重复施加和释放施加的压力;施加的压力在10、15和20 mmHg之间变化，持续时间在3、5和8分钟之间变化。PO 2随压力的增加而降低，随压力的释放而恢复，且随着压力施加次数的增加，PO 2波动更大。对于较长的压力施加时间，释放压力后需要更多的时间来恢复PO 2。在改变压力施加的直径的单独试验中，发现PO 2的变化不仅与施加的压力的力有关，而且与施加压力的面积有关。

项目成果

加圧による皮下組織内酸素濃度および血液透過性の測定

加压测量皮下组织氧浓度和血液渗透性

• 发表时间: 2010
• 作者: 松田綾音;門馬靖武;千葉宏毅;田畑雅央;遠藤智之;石井誠一;加賀谷豊;金塚完;三木将仁
• 通讯作者: 三木将仁