Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feeding

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Vagal afferents sense the peripheral factors and convey these signals to the brain to regulate food intake. In present study, I measured cytosolic Ca^<2+> concentration in the primary cultured neurons of vagal afferents to investigate whether peripheral factor directly act on the vagal afferents. We have found that some of pancreatic and gastrointestinal hormones activate vagal afferents neurons directly. Moreover, the insulin action to vagal afferent neurons was suppressed by ghrelin and potentiated by GLP-1.