Development of multielement measurement method for exhaustive study of essential elements in cells

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We have developed a new analytical system based on plasma mass spectrometry to realize a single cell analysis of trace elements. The system is constructed of inductively coupled plasma mass spectrometry and its new sample introduction interface that can directly introduce cells into the plasma. The system can get a snap shot of the moment of the decomposition of a cell in the plasma, and can measure multielement in the cell at a time. In the application for multielement analysis of a single yeast cell, Mg, P, and Zn can successfully be measured in single yeast cells.