A Flow Microreactor Approach to Protecting-group Free Synthesis

我们已经开发了一种流动微反应器的方法来保护基团自由的合成。在本研究中，我们发现使用流动微反应器系统可以有效地用于（2）带有亲电官能团如烷氧羰基的芳基锂的生成和反应，氰基和硝基，这样的转化是非常困难的或不可能与传统的macrobatch系统（2）带有酮羰基的芳基锂的生成和反应，这种转化用常规的大批量体系是不可能的，（3）孔雀石绿绿色的形式化合成。

We have developed a flow-microreactor approach to protecting-group free synthesis. In this research, we have found that the use of flow microreactor systems could be effective method for(2)generation and reactions of aryllithiums bearing electrophilic functional groups such as alkoxycarbonyl, cyano and nitro groups that such transformations are very difficult or impossible with a conventional macrobatch system(2)generation and reactions of aryllithiums bearing ketone carbonyl groups that such transformations are impossible with a conventional macrobatch system, and(3)the formal synthesis of Malachite green.