Analysis of the X chromosome inactivation-reactivation cycle throughout the mouse life cycle

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It is known that the X chromosome of female mammals shows inactivation-reactivation cycles throughout the life cycle, especially at the peri-implantation stage, the changes of the X chromosome activity occur during short period. In this study, it was indicated that the re-inactivation of the X chromosome in the epiblast, the future embryo proper, occurs just after implantation. Furthermore, the dynamics of the DNA methylation of the inactive X linked genes during the X reactivation in primordial germ cells was elucidated.