Molecular characterization of selective lipid transport using cocoon color genes in the silkworm

控制β-胡萝卜素从昆虫血淋巴转运到丝腺的F基因编码SCRB 15，SCRB 15是属于CD 36超家族的跨膜蛋白。SCRB15与Cameo2是旁系同源的，Cameo2由控制叶黄素转运的C基因编码。阐明SCRB 15和Cameo 2之间类胡萝卜素特异性差异的分子机制将为CD36超家族的选择性脂质转运提供机制见解，这对于传染性病原体的传播也很重要

The F gene, which controls the transport of beta-carotene from insect hemolymph into the silk gland, encoded SCRB15, a transmembrane protein which belongs to the CD36 superfamily. SCRB15 is paralogous to Cameo2, which is encoded by the C gene, which controls the transport of lutein. Elucidation of the molecular mechanisms for the difference in carotenoid specificity between SCRB15 and Cameo2 will provide mechanistic insights for the selective lipid transport by the CD36 superfamily, which is also important for the transmission of infectious pathogens