The identification and molecular function of nuclear glycosyl transferase complex

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In this research, we focused on the molecular function of O-linked N-acetylglucosamine transferase(OGT), which was identified as a co-activator of nuclear receptor(NR)-mediated transcription in our previous study. To understand the molecular basis for OGT to activate transcription from chromatin, we purified its interacting partners by affinity purification, and identified several chromatin regulatory factors including histone methyltransferases. In addition, we found that histone was a novel substrate for OGT. Together, this modification might be a substantial epigenetic code for the regulation of eukaryotic gene expression network.