A genome-wide analysis of let-7 micron-dependent developmental timing pathway

在精确的时间表下，多细胞生物体的发育受到严格的监管。为了揭开多细胞生物体发育计时的分子机制，我使用线虫秀丽线虫作为模式生物。我鉴定了与let-7 microRNA途径有关的基因，这是幼虫向成虫过渡所必需的。我发现let-7microRNA途径受几个转录调节因子以及受体和染色质重塑因子的控制。

The development of multicellular organisms is tightly regulated under a precise time schedule. To unravel the molecular mechanisms underlying developmental timing in multicellular organisms, I used the nematode Caenorhabditis elegans as the model organism. I identified and characterized genes involved in the let-7 microRNA pathway, which is essential for the larva-to-adult transition. I found that the let-7 microRNA pathway is controlled by several transcription regulatory factors and receptor and chromatin-remodeling factors.