Effects of mechanical stresses on neural stem/progenitor cells

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Accumulated evidence suggests that the stress, including physical stress influence on neural progenitor cell fates, which resulted in various neuronal disorders. The aim of present study is to understand the underlying mechanisms how those stress, especially physical stresses, regulate NPC functions. Initially, because we found that the expression of progranulin(PGRN) is induced in response to those stresses, we analyzed and reported the effects of PGRN on NPC functions. We also found that nano materials induced physical stress on NPCs and controlled cellular functions.