Regulation of dopamine function by amino acid intake via modulation of tryptophan metabolism
Regulation of dopamine function by amino acid intake via modulation of tryptophan metabolism
批准号:
22780123
负责人:
FUKUWATARI Tsutomu
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
本研究的目的是获得饮食对维持脑功能的发现。在体内和体外,摄入支链氨基酸,亮氨酸或异亮氨酸抑制色氨酸代谢产物犬尿烯酸的产生,并增强大鼠大脑中神经递质多巴胺的释放。这些结果表明,饮食控制犬尿氨酸的产生可以调节正常愤怒时多巴胺的释放。
英文摘要
The purpose of this study is to obtain findings for maintain brain function by diet. In vivo and in vitro, intake of branched chain amino acids, leucine or isoleucine suppressed production of tryptophan metabolite kynurenic acid, and enhanced release of neurotransmitter dopamine in rat brain. These results suggest that dietary manipulation of kynurenic production can modulate dopamine release in normal rage.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ラット脳における分岐鎖アミノ酸によるトリプトファン代謝産物キヌレン酸産生抑制
支链氨基酸抑制大鼠脑中色氨酸代谢物犬尿酸的产生
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[福渡努, 丸山明子, 東山沙織, 佐野光枝, 柴田克己]
通讯作者:
柴田克己
High branched-chain amino acid diets suppress kynurenic acid production in rat brain
高支链氨基酸饮食抑制大鼠脑中犬尿酸的产生
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Fukuwatari T, Maruyama A, HIgashiyama S, Sano M, Shibata K]
通讯作者:
Shibata K
Establishment of dietary environment for regulation of higher brain function via control of peripheral amino acids metabolism
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批准号:18K10997
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2018
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负责人:FUKUWATARI Tsutomu
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依托单位:
Regulation of higher brain function via control of tryptophan metabolite kynurenic acid by amino acid intake
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批准号:24614010
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2012
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负责人:FUKUWATARI Tsutomu
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依托单位:
Study on modulation of dopaminergic function via manipulation of tryptophan metabolism
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批准号:20780100
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2008
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负责人:FUKUWATARI Tsutomu
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依托单位:
海外基金