Function analysis of Eph/ephrin signals in angiogenesis

本研究旨在探讨Eph/ephrin在白细胞粘附和血管生成逆转中的作用。为了需要的数据，进行了初步的实验和功能分析。结果表明，Eph/ephrin在血管中表达，并与白细胞/巨噬细胞和内皮细胞粘附，细胞突起含有高密度的肌动蛋白纤维。这些结果表明，血细胞的伪足和内皮细胞膜收缩引起的细胞间隙扩张形成了血细胞的细胞间迁移途径。

In this study, it is intended to determine the function of Eph/ephrin in leucocyte-adhesion and inversion in angiogenesis. To require the data, preliminary experiments and functional analyses were conducted. It was determined that Eph/ephrin were expressed in blood vessels, and they adhered to leukocyte/macrophage and endothelial cells with cell processes contained high density actin fiber. These results indicate that the intercellular migration pathway for blood cells is formed by the pseudopodia of blood cells and the dilation of intercellular space by the membrane retraction in endothelial cells.