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Mechanisms Underlying The Seasonal Function In Pars Tuberalis

结节部季节性功能的机制

基本信息

批准号：
22780266
负责人：
NAKAO Nobuhiro
金额：
$ 2.58万
依托单位：
Nippon Veterinary and Life Science University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22780266/
关键词：
下垂体隆起葉 Eyesabsent3 甲状腺刺激ホルモン光周性ニホンウズラ Eyes absent 3

项目摘要

Animals living outside the tropical region perform seasonalreproduction in accordance with changes in the photoperiod. Recent studies have demonstrated that pars tuberalis(located at the base of the anterior pituitary gland) plays an important role in photoperiodic time measurement. However, endocrine functions of the pars tuberalis have not been completely elucidated. To evaluate the potential role of the pars tuberalis in endocrine function, we observed the function of the Eyes absent 3(EYA3) since EYA3 mRNA expression was previously observed in the pars tuberalis in a time-dependent manner. The function of EYA3 in the pars tuberalis may not only be coactivation of transcription but also contribution to several other functions.

生活在热带地区以外的动物根据光周期的变化进行季节性繁殖。最近的研究表明，结节部（位于垂体前叶基部）在光周期时间测量中起着重要作用。然而，结节部的内分泌功能尚未完全阐明。为了评估结节部在内分泌功能中的潜在作用，我们观察了眼缺失3（EYA 3）的功能，因为先前在结节部中以时间依赖性方式观察到EYA 3 mRNA表达。EYA 3在结节部的功能可能不仅是转录的共激活，而且还参与了其他一些功能。