Development of target-specific gene therapy system by using cell surface adhesive interferon.
Development of target-specific gene therapy system by using cell surface adhesive interferon.
批准号:
22790034
负责人:
TAKAHASHI Yuki
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
In the present study, we developed IFN-γderivative that can adhere on cellular surface in order to selectively increase IFN-γconcentration at gene delivery site. Developed IFN-γwas demonstrated to be able to adhere on the cell surface and selective biological activity obtained by gene delivery of the developed IFN-γderivative was specific in the gene-delivered organ. We found that the developed system was effective in reducing adverse side effect without reducing antitumor effect at target tissue compared to the normal IFN-γgene therapy system.
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Design and Hydrodynamic Gene Transfer of 'Sticky' interferon-γ for Liver-Directed Gene Therapy of Hepatic Metastasis of Cancer Cells
用于癌细胞肝转移的肝脏定向基因治疗的“粘性”干扰素-γ的设计和流体动力学基因转移
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ando M, Takahashi Y, et al]
通讯作者:
et al
Design and hydrodynamic gene transfer of 'sticky' IFNγfor liver-directed gene therapy.
用于肝脏定向基因治疗的“粘性”IFNγ 的设计和流体动力学基因转移。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Mitsuru Ando, Yuki Takahashi, Hanae Mukumoto, Makiya Nishikawa, Yoshihiko Watanabe and Yoshinobu Takakura.]
通讯作者:
Yoshihiko Watanabe and Yoshinobu Takakura.
機能性ペプチド融合によるIFN-γ時空間制御
功能性肽融合对 IFN-γ 的时空调节
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[安藤満, 高橋有己, 西川元也, 高倉喜信]
通讯作者:
高倉喜信
Design and gene delivery of 'sticky' interferonγto increase the effect/side-effect ratio for liver-directed interferon-γgene therapy
“粘性”干扰素 γ 的设计和基因递送,以提高肝脏定向干扰素 γ 基因治疗的效果/副作用比
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Mitsuru Ando, Yuki Takahashi, Hanae Mukumoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura]
通讯作者:
Yoshinobu Takakura
体内動態制御によるインターフェロン遺伝子治療の最適化
通过控制药代动力学优化干扰素基因治疗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[高橋有己, 西川元也, 渡部好彦, 高倉喜信]
通讯作者:
高倉喜信
共 7 条
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