Characterization of signaling pathways that are regulated through cell surface molecular interaction in B cell lymphoma.
Characterization of signaling pathways that are regulated through cell surface molecular interaction in B cell lymphoma.
批准号:
22790071
负责人:
KOTANI Norihiro
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Many plasma membrane-resident proteins collaborate with other molecules by molecular interactions in a variety of biological events. Herein, we have studied interacted molecules associated with CD20-rituximab complex on B cell lymphoma cells. We found some cell surface molecules, such as FGFR3, HLA class II, and HSP-90 are interacted with CD20-rituximab complex. Above all, FGFR3 possibly plays important role for efficacy of rituximab-dependent cytotoxic effect through cell cycle signaling pathways.
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抗体医薬の効能や安全性を向上させる分子標的治療の標的分子探索
靶点分子寻找分子靶向治疗,提高抗体药物的疗效和安全性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小谷典弘, 石浦嘉人]
通讯作者:
石浦嘉人
Spatiotemporally-regulated interaction between beta1 integrin and ErbB4 that is involved in Fibronectin-dependent cell migration
β1 整合素和 ErbB4 之间的时空调节相互作用参与纤连蛋白依赖性细胞迁移
DOI:
--
发表时间:
2011
期刊:
J Biochem
影响因子:
2.7
作者:
[Yamashita R, Kotani N^*, Ishiura Y, Higashiyama S, Honke K]
通讯作者:
Honke K
DOI:
10.1016/j.bbrc.2010.04.092
发表时间:
2010-05-28
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ishiura, Yoshihito, Kotani, Norihiro, Honke, Koichi]
通讯作者:
Honke, Koichi
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Honke K, Miyagawa-Yamaguchi A, Kotani N]
通讯作者:
Kotani N
Divergence of cell surface molecular interactions in treatment of B-cell lymphoma cells with different anti-CD20 antibody clones
不同抗CD20抗体克隆治疗B细胞淋巴瘤细胞时细胞表面分子相互作用的差异
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kotani N, Ishiura Y, Yamashita R, Honke K]
通讯作者:
Honke K
共 13 条
Characterization of cell surface molecular interactions in virus-infected host cell
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批准号:19790060
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.21万
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财政年份:2007
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负责人:KOTANI Norihiro
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依托单位:
海外基金