Potential toxicity induced by organotin compounds via PPAR_γsignaling pathway

野生型小鼠给药后，胸腺重量减少，脂肪重量增加，PPAR_γ基因表达增强。胸腺中的AP2和CD36。此外，TPT还能促进胸腺脂肪生成。另一方面，TPT在PPAR中的应用效果。杂合基因敲除小鼠的基因频率往往低于野生型小鼠。流式细胞仪分析显示胸腺和脾细胞数量明显减少，胸腺原始T细胞百分率略有下降。提示TPT通过PPAR_γ促进胸腺萎缩、成脂和衰老。

TPT administration in the wild-type mice decreased the thymus weight, increased adipose weight and enhanced the mRNA levels of PPAR_γ. aP2 and CD36 in the thymus. Furthermore, TPT promoted the thymic adipogenesis. On the other hand, the effect of TPT administration in PPAR. hetero-knockout mice tended to be lower than the wild-type mice. Flow cytometric analysis demonstrated a significant decrease in the thymus and spleen cell number and a slight decrease in the rate of naive T cell from the thymus. These results suggest that TPT promotes thymic atrophy, adipogenesis and aging via PPAR_γ.