Potential toxicity induced by organotin compounds via PPAR_γsignaling pathway

野生型小鼠给予TPT后胸腺重量降低，脂肪重量增加，PPAR_γ mRNA水平升高。胸腺中的aP2和CD36。此外，TPT促进胸腺脂肪的形成。另一方面，TPT给药对PPAR的影响。异基因敲除小鼠比野生型小鼠更低。流式细胞术分析显示胸腺和脾脏细胞数量明显减少，胸腺幼稚T细胞率略有下降。提示TPT通过PPAR_γ促进胸腺萎缩、脂肪形成和衰老。

TPT administration in the wild-type mice decreased the thymus weight, increased adipose weight and enhanced the mRNA levels of PPAR_γ. aP2 and CD36 in the thymus. Furthermore, TPT promoted the thymic adipogenesis. On the other hand, the effect of TPT administration in PPAR. hetero-knockout mice tended to be lower than the wild-type mice. Flow cytometric analysis demonstrated a significant decrease in the thymus and spleen cell number and a slight decrease in the rate of naive T cell from the thymus. These results suggest that TPT promotes thymic atrophy, adipogenesis and aging via PPAR_γ.