Polyphenolic constituents from Chestnut needles and their biological activities

板栗针中的多酚成分及其生物活性

• 批准号: 22790141
• 负责人: YOSHIMURA Morio
• 金额: $ 2.41万
• 依托单位: Matsuyama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790141/
• 关键词: ポリフェノール; 加水分解性タンニン; エラグ酸誘導体

We examined the polyphenolic constituents in chestnut needles and isolated fourteen phenolics including hydrolyzable tannins and ellagic acid derivative. Also, ellagic acid 3-C-glucoside which was derived from hydrolyzable tannins and was not yet isolated from natural resources was obtained. All the isolates showed potent antioxidative activities evaluated by ORAC test and SOD-like activity. Hydrolyzable tannins also exert tyrosinase inhibitory effect meanwhile ellagic acids which are known to have skin-whitening ability showed no activity. Additionally, ellagic acid 3-C-glucoside showed potent inhibitory effect against melanogenesis of melanoma B16 cells than the positive control of arbutin with low cytotoxicity.

对板栗针叶中的多酚类物质进行了分析，分离出14种多酚类物质，包括可水解单宁和鞣花酸衍生物。此外，还获得了鞣花酸3- c -葡萄糖苷，该苷是从可水解单宁中分离得到的，尚未从自然资源中分离得到。经ORAC试验和sod样活性评价，各菌株均表现出较强的抗氧化活性。水解单宁酸对酪氨酸酶也有抑制作用，而鞣花酸对皮肤美白无抑制作用。此外，鞣花酸3- c -葡萄糖苷对黑色素瘤B16细胞的黑色素生成具有较强的抑制作用，而阳性对照熊果苷具有较低的细胞毒性。

项目成果

栗イガに含まれるポリフェノール成分

板栗毛中含有的多酚成分

• 发表时间: 2012
• 作者: 門田佳人;柳川真澄;中矢誠子;川上隆茂;佐藤政男;鈴木真也;好村守生,天倉吉章,吉田隆志;好村守生,天倉吉章,吉田隆志
• 通讯作者: 好村守生,天倉吉章,吉田隆志

Polyphenolic constituents of Castanea crenata needles

板栗针的多酚成分

• 发表时间: 2012
• 作者: 門田佳人;柳川真澄;中矢誠子;川上隆茂;佐藤政男;鈴木真也;好村守生,天倉吉章,吉田隆志
• 通讯作者: 好村守生,天倉吉章,吉田隆志