Blood brain barrier state of a disease the chronic obstructive pulmonary disease-Central side effect measures of the inhalational anti-cholinergic drugs

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We examined a change of the blood-brain barrier(BBB) function and the central nerve transition of the anticholinergic drugs in the chronic obstructive pulmonary disease(COPD). As result, in COPD model mouse, tight junction function of the BBB was decreased, and there is possibility that the intracerebral transmissiveness of the anticholinergic drug were aggravated. Therefore, in COPD, the brain internal transmigration of drugs are accelerated by BBB disfunction, and it was thought that expression of the central side effects such as cognitive function disorders are easy.