Functional analysis of NLRR-4 gene in the mouse olfactory system during development.

在这项研究中，我调查了NLRR-4的表达在嗅觉系统在发展过程中。我发现NLRR-4在嗅上皮、嗅球和梨状皮质中表达。在犁鼻器中，NLRR-4在信息素受体V2 R阳性的表皮细胞中被检测到，而在V1 R阳性的细胞中未检测到。在行为分析中，NLRR-4基因敲除的雄性小鼠表现出对其他小鼠的攻击性反应和对雄性尿液的回避行为的减少。这些结果提示NLRR-4参与了嗅觉系统的发育和犁鼻系统的功能。

In this study, I investigated the expression of NLRR-4 in the olfactory system during development. I found that NLRR-4 was expressed in the olfactory epithelium, olfactory bulb, and piriform cortex. In the vomeronasal organ, NLRR-4 was detected in pheromone receptor V2R-positive-epiterial cells but not in V1R-pisitive cells. In the behavioral analysis, NLRR-4-gene knockout male mice showed reduction of the aggressive responses for the other mile mice and the avoidance behavior for male urine. These results suggested that NLRR-4 was involved in the development of the olfactory system and the function of vomeronasal system.