Cell therapy for Muscular Dystrophy using myogenic progenitor cells derived from human iPS cells
Cell therapy for Muscular Dystrophy using myogenic progenitor cells derived from human iPS cells
批准号:
22790284
负责人:
SAKURAI Hidetoshi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
我们开发了一种高效、简便的方法,利用来自多个供体的外体载体,包括两个仅检测到一个HLA单倍型的载体,来制备无整合的人IPSCs。这些IPSCs在体内和体外均能有效地分化为各种类型的细胞。这两个假定为人类白细胞抗原纯合子的IPSC株在主要的人类白细胞抗原基因座上匹配大约20%的日本人。
英文摘要
We developed an efficient and simple method to generate integration-free human iPSCs with episomal plasmid vectors from multiple donors, including two in which only one HLA haplotype was detected. These iPSCs were effectively differentiated into various cell types in vivo and in vitro. The two putatively HLA-homozygous iPSC lines match~ 20% of the Japanese population at major HLA loci.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
METHOD OF INDUCING DIFFERENTIATION FROM PLURIPOTENT STEM CELL TO SKELETAL MUSCLE PROGENITOR CELLS
诱导多能干细胞向骨骼肌祖细胞分化的方法
DOI:
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发表时间:
2010
期刊:
影响因子:
--
作者:
[]
通讯作者:
Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability
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批准号:26430053
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2014
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负责人:SAKURAI Hidetoshi
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依托单位:
Modeling Duchenne muscular dystrophy using patient-derived iPS cells
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批准号:24790383
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
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财政年份:2012
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负责人:SAKURAI Hidetoshi
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依托单位:
海外基金