Functional conversion of tumor-supporting myeloid cells to tumoricidal effectors by dsRNA adjuvant
Functional conversion of tumor-supporting myeloid cells to tumoricidal effectors by dsRNA adjuvant
批准号:
22790371
负责人:
SHIME Hiroaki
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
In many cancer patients, immune system is subverted by immunosuppressive cells as well as tumor-derived factors, which contributes to tumor progression. Tumor-associated macrophages with immunosuppressive, M2-like phenotype support the tumor growth by several mechanisms. Here, we show that double-stranded RNA(dsRNA) adjuvant induces growth retardation of 3LL tumor by converting tumor-supporting macrophages to tumoricidal effectors through the activation of TLR3-TICAM-1 signaling pathway
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樹状細胞と腫瘍浸潤マクロファージのアジュバント応答
树突状细胞和肿瘤浸润巨噬细胞的佐剂反应
DOI:
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发表时间:
2010
期刊:
影响因子:
--
作者:
[西村孝司, 北村秀光, 他, Shime H, Aly HH, 児島絢子, Shime H, Shime H, 志馬寛明, Seya T, Shime H, 志馬寛明, 志馬寛明, 志馬寛明, 志馬寛明]
通讯作者:
志馬寛明
北海道医療新聞(2012. 1)
北海道医学报(2012.1)
DOI:
--
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影响因子:
--
作者:
[]
通讯作者:
Establishment of HCV replication in mouse hepatocytes through the modulation of mouse innate immune response
通过调节小鼠先天免疫反应在小鼠肝细胞中建立 HCV 复制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[西村孝司, 北村秀光, 他, Shime H, Aly HH]
通讯作者:
Aly HH
Tumoricidal activity of tumor-associated macrophages activated by RNA adjuvant
RNA佐剂激活肿瘤相关巨噬细胞的杀肿瘤活性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[西村孝司, 北村秀光, 他, Shime H, Aly HH, 児島絢子, Shime H, Shime H]
通讯作者:
Shime H
Newton Doctor(2012. 3)
牛顿博士(2012.3)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 30 条
Regulation of function of tumor-infiltrating myeloid cells by RNA adjuvant
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批准号:24590470
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:SHIME Hiroaki
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依托单位:
Analysis of the immune response enhanced by tumor-secreted lactic acid
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批准号:19790302
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.36万
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财政年份:2007
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负责人:SHIME Hiroaki
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依托单位:
海外基金