Interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction

点击翻译按钮获取中文摘要

This study was conducted to elucidate an interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction (CR). We confirmed that CR reduced the protein expression level of p53 in the tissues and age-related increases in the mRNA levels of Cdkn2a and p21, those are known to be regulated by p53. During the period of the present study, we could not evaluated the interaction of p53 in vivo, because of difficulty of propagation of p53 (m/+) mice, in which an active form of p53 is overexpressed. However, the present study demonstrated that FoxO3 is needed for the life-extending effectof CR; by contrast, FoxO1 plays an important role for the anti-neoplastic effect ofCR.