Development of a mouse model of the infection with Streptococcus dysgalactiae subspecies equisimilis.

踝关节炎是由停乳链球菌亚种类马链球菌RE378菌株单次皮下感染到人CD46表达转基因（Tg）小鼠的两个后足垫中诱导的，该菌株分离自因败血症而患有多器官衰竭的患者。CD 46 Tg小鼠后踝切片中的组织病理学发现显示了与滑膜炎症相关的破骨细胞形成的刺激。 比较基因组序列分析显示，43个预测的毒力相关因子，包括推定的粘附蛋白和核酸酶。

Ankle arthritis was induced by a single subcutaneous infection od the Streptococcus dysgalactiae subspecies equisimilis strain RE378, which was isolated from a patient suffering from multiple organ failure due to septicaemia, into both hind footpads of human CD46-expressing transgenic(Tg) mice. The histopathological findings in the hind ankle sections of CD46 Tg mice showed the stimulation of osteoclast formation associated with inflammation of the synovial membrane. The comparative genome sequence analysis revealed that the 43 predicted virulence-related factors including putative adhesion proteins and nucleases.