Analysis of the mechanism of Salmonella-induced colitis.

鼠伤寒沙门氏菌引起急性胃肠炎。这种细菌有三种III型分泌系统（SPI-1，SPI-2和鞭毛），这是肠道炎症所必需的。在本研究中，我们试图通过T3 SS-2来鉴定分泌到宿主细胞中的效应物。不幸的是，我们不能在链霉素预处理的小鼠模型中鉴定与急性肠道炎症相关的SPI-2效应物。然而，我们发现SpvC，SPI-1和SPI-2 T3 SS效应器，在感染的早期阶段逃避肠粘膜中的免疫应答，并在感染的晚期阶段促进细菌传播。

Salmonella enterica serovar Typhimurium causes acute gastroenteritis. This bacterium has three Type III secretion systems(SPI-1, SPI-2 and flagella), which are required for intestinal inflammation. In this study, we tried to identify effectors secreted into host cells through T3SS-2.Unfortunately, we could not identify the SPI-2 effector associated with acute intestinal inflammation in a streptomycin pretreated mouse model. However, we showed that SpvC, both SPI-1 and SPI-2 T3SS effector, evades the immune response in the intestinal mucosa in the early stage of infection and facilitates bacterial dissemination at late stages of infection.