Analysis of the mechanism of Salmonella-induced colitis.

鼠伤寒沙门氏菌可引起急性胃肠炎。这种细菌有三种III型分泌系统(SPI-1、SPI-2和鞭毛)，这是肠道炎症所必需的。在这项研究中，我们试图确定通过T3SS-2分泌到宿主细胞的效应物。不幸的是，我们无法在链霉素预处理的小鼠模型中确定与急性肠炎相关的SPI-2效应物。然而，我们发现SpvC，SPI-1和SPI-2 T3SS效应器，在感染早期逃避肠道粘膜的免疫反应，在感染后期促进细菌扩散。

Salmonella enterica serovar Typhimurium causes acute gastroenteritis. This bacterium has three Type III secretion systems(SPI-1, SPI-2 and flagella), which are required for intestinal inflammation. In this study, we tried to identify effectors secreted into host cells through T3SS-2.Unfortunately, we could not identify the SPI-2 effector associated with acute intestinal inflammation in a streptomycin pretreated mouse model. However, we showed that SpvC, both SPI-1 and SPI-2 T3SS effector, evades the immune response in the intestinal mucosa in the early stage of infection and facilitates bacterial dissemination at late stages of infection.