Screening of the target genes of IL-6 Amp that promotes autoimmune diseases

IL-6 Amp在自身免疫性疾病和慢性炎症中起重要作用。为了确定IL-6Amp的靶分子，我们采用了多种全基因组筛选方法。结果，一种炎性趋化因子CCL20被确定为关键靶点，它可以促进T细胞亚群的招募。根据这些发现，提出了器官特异性自身免疫性疾病的“四步模型”。最后，一种在自身免疫性疾病患者中高度存在的可溶性分子被发现对调节IL-6-Amp具有重要作用，这为药物开发打开了新的可能性。

IL-6 Amp is important for autoimmune diseases and chronic inflammation. In order to identify the target molecules of IL-6 Amp, several genome-wide screening methods were carried out. As results, an inflammatory chemokine Ccl20 that enhances the recruitment of a subset of T cells is identified as a key target. With those findings," a four-step model" for organ-specific autoimmune diseases was presented. Finally, a soluble molecule highly presented in the patients with an autoimmune disease was found to be important for regulating IL-6 Amp, that opens new possibilities for the drug development.