Study on the mechanism of hypertension via endogenous digitalis-like factor in central nervous system
Study on the mechanism of hypertension via endogenous digitalis-like factor in central nervous system
批准号:
22790534
负责人:
YOSHIKA Masamichi
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
内源性地黄样因子(Endogenous digitalis-like factor, EDLF)存在于中枢神经系统和外周组织中。瓦巴因存在于下丘脑,受肾素血管紧张素醛固酮系统(RAAS)调控。一种属于丁二烯内酯的新型EDLF可能从下丘脑永生化细胞系分泌。血管紧张素还可调节肾上腺分泌海马蟾毒蛋白和海马蟾毒毒素。
英文摘要
Endogenous digitalis-like factor(EDLF) exist in the central nerve system as well as peripheral tissue. Ouabain is existed in hypothalamus and regulated by renin angiotensin aldosterone system(RAAS). A novel EDLF belonged to bufadienolide may be secreted from hypothalamus immortalized cell line. Moreover angiotensin should regulate to secret marinobufagenin and marinobufotoxin from adrenal gland.
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DOI:
10.1016/j.neuint.2011.04.019
发表时间:
2011-08
期刊:
Neurochemistry International
影响因子:
4.2
作者:
[M. Yoshika;Y. Komiyama;Hakuo Takahashi]
通讯作者:
M. Yoshika;Y. Komiyama;Hakuo Takahashi
EVIDENCE FOR A MARINOBUFAGENIN-LIKE IMMUNOREACTIVITY IN CENTRAL NERVOUS SYSTEM
中枢神经系统中海蟾蜍配基样免疫反应性的证据
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Masamichi Yoshika, Yutaka Komiyama, Hakuo Takahashi]
通讯作者:
Hakuo Takahashi
DOI:
10.1093/eurheartj/ehr106
发表时间:
2012-06-01
期刊:
EUROPEAN HEART JOURNAL
影响因子:
39.3
作者:
[Kamimura, Daisuke, Ohtani, Tomohito, Yamamoto, Kazuhiro]
通讯作者:
Yamamoto, Kazuhiro
高血圧発症機序における内因性ジギタリスの臨床検査学的研究
内源性洋地黄在高血压发生机制中的临床实验研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[吉賀正亨, 小宮山豊, 高橋伯夫]
通讯作者:
高橋伯夫
DOI:
10.1038/hr.2011.105
发表时间:
2011-11
期刊:
HYPERTENSION RESEARCH
影响因子:
5.4
作者:
[Takahashi, Hakuo, Yoshika, Masamichi, Komiyama, Yutaka, Nishimura, Masato]
通讯作者:
Nishimura, Masato
共 11 条
Mechanism of production, secretion and hypertension in the endogenous digitalis like factors mediating lipolytic enzyme
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批准号:17K08997
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2017
-
负责人:YOSHIKA Masamichi
-
依托单位:
Mechanism of production, secretion and hypertension in the endogenous digitalis like factors using mass spectrometry immunoassay
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批准号:26460662
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
-
财政年份:2014
-
负责人:YOSHIKA Masamichi
-
依托单位:
Study on the mechanism of production and secretion in central nervous system by imaging mass spectrometry
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批准号:24790567
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.91万
-
财政年份:2012
-
负责人:YOSHIKA Masamichi
-
依托单位:
海外基金