Relationship between environmental factors and childhood allergies

环境因素与儿童过敏的关系

• 批准号: 22790546
• 负责人: TSUJI Mayumi
• 金额: $ 2.33万
• 依托单位: University of Occupational and Environmental Health, Japan (2011-2012)Kumamoto University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790546/
• 关键词: 母子保健; アレルギー・喘息; 社会医学; 分子疫学; アレルギー

Study purpose is to search the biomarkers indicating relations of the childhood allergies and environmental factors.[Material and Methods] We did questionnaire survey and the measurement of the specific IgE levels, serum level of PCBs and mRNA by using the children's blood.[Result] We extracted 30 preschool children (healthy children 15, asthmatic children 15) from subjects (N=200). (1) IL-8 mRNA expression was high in the children who were asthma and had high level of PCB concentration. (2) IL-22mRNA expression was high in the children who were IgE positive and had high level of PCB concentration.[Conclusion] Our results suggested that the possibility that IL-8 and IL -22 were useful biomarkers for environmental exposure in allergic children.

本研究的目的是寻找儿童过敏与环境因素关系的生物标志物。[材料与方法]采用儿童血液进行问卷调查、特异性IgE水平、血清多氯联苯和mRNA水平的测定。[结果]从受试者中抽取了30名学龄前儿童（健康儿童15名，哮喘儿童15名）（N=200）。(1)哮喘组和高浓度PCB组IL-8 mRNA表达明显增高。(2)在IgE阳性和PCB浓度高的儿童中IL-22 mRNA表达较高。[结论] IL-8和IL-22可能是过敏儿童环境暴露的生物标志物。

项目成果

IL-22 mRNA expression in blood samples as a useful biomarker for assessing the adverse health effects of PCBs on allergic children.

• DOI: 10.3390/ijerph9124321
• 发表时间: 2012-12
• 期刊: International journal of environmental research and public health
• 作者: Tsuji M;Kawamoto T;Koriyama C;Matsumura F
• 通讯作者: Matsumura F

未就学時における喘息・血清PCB濃度・IL8/COX-2の関係

学龄前哮喘、血清PCB浓度和IL8/COX-2之间的关系

• 发表时间: 2012
• 作者: 神農雅秀;他;内藤久雄;辻真弓
• 通讯作者: 辻真弓

Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese

日本哮喘和非哮喘患者血液样本中多氯联苯血清水平与 IL-8 mRNA 表达的关系

• 发表时间: 2012
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: 林由美;山岸希;伊藤由起;内藤久雄;那須民江;Mayumi Tsuji
• 通讯作者: Mayumi Tsuji

母親のメンタルヘルスと児のアレルギー疾患との関係

孕产妇心理健康与儿童过敏性疾病的关系

• 发表时间: 2013
• 作者: 林由美;山岸希;伊藤由起;内藤久雄;那須民江;Mayumi Tsuji;Yetti H;辻 真弓
• 通讯作者: 辻 真弓

Nongenomic action mechanisms of TCDD through activation of AHR in NCL-H441 human lung epithelial cells

TCDD 通过激活 NCL-H441 人肺上皮细胞 AHR 的非基因组作用机制

• 发表时间: 2012
• 作者: 内藤久雄;玉田葉月;植草良輔;北森一哉;柳場由絵;王棟;那須民江;Mayumi Tsuji
• 通讯作者: Mayumi Tsuji