Relationship between environmental factors and childhood allergies

本研究的目的是寻找儿童过敏与环境因素关系的生物标志物。[材料与方法]采用问卷调查、血清特异性IgE水平、PCBs及mRNA水平测定等方法对儿童进行调查。[结果]从200名受试者中抽取30名学龄前儿童（健康儿童15名，哮喘儿童15名）。(1)哮喘组和高浓度PCB组IL-8 mRNA表达明显增高。(2)在IgE阳性和PCB浓度高的儿童中IL-22 mRNA表达较高。[结论] IL-8和IL-22可能是过敏儿童环境暴露的生物标志物。

Study purpose is to search the biomarkers indicating relations of the childhood allergies and environmental factors.[Material and Methods] We did questionnaire survey and the measurement of the specific IgE levels, serum level of PCBs and mRNA by using the children's blood.[Result] We extracted 30 preschool children (healthy children 15, asthmatic children 15) from subjects (N=200). (1) IL-8 mRNA expression was high in the children who were asthma and had high level of PCB concentration. (2) IL-22mRNA expression was high in the children who were IgE positive and had high level of PCB concentration.[Conclusion] Our results suggested that the possibility that IL-8 and IL -22 were useful biomarkers for environmental exposure in allergic children.