Effects of environmental chemicals on the hematopoiesis of iPS cells
Effects of environmental chemicals on the hematopoiesis of iPS cells
环境化学物质对 iPS 细胞造血的影响
批准号：
22790552
负责人：
ITO Tomohiro
金额：
$2.58万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
翻译
利用iPS细胞检测了邻苯二甲酸酯类化合物对造血功能的影响。在该系统中，DEHP抑制iPS细胞的造血祖细胞的出现，而DEHP的代谢物MEHP促进了iPS细胞的造血祖细胞的出现。也有人认为，它们的作用是独立于雌激素受体和过氧化体增殖物激活受体的。
英文摘要
By using iPS cells, effects of phthalate esters on the hematopoiesis were examined. In that system, DEHP suppressed the appearance of hematopoietic progenitor from iPS cells while MEHP, a metabolite of DEHP, accelerated it. It was also suggested that their effects are caused independently of estrogen receptor and peroxisome proliferators-activated receptor.
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会议论文
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依托单位：
海外基金
