Epigenetics of mechanism of augmentation for traumatic brain edema under ethanol consumption : role of microRNA

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It has been well known that ethanol has the detrimental effect on traumatic brain injury. We previously reported that ethanol augments brain edema after brain contusion. In this study, to elucidate the mechanism of brain edema augmentation by ethanol, rat traumatic brain injury model and astrocyte culture experimnents were performed. The increase of aquaporin-4, an water channel, and the decrease of sodium ion concentration had the effects on the augmentation of brain edema under ethanol consumption. These findings suggest that the inhibitor of aquaporin-4 and hyponatremia may be a new treatment of brain edema aftet traumatic brain injury.