The role of HNE in the phosphorylation of EGFR for the development of esophageal squamous cell carcinoma.

HNE 在 EGFR 磷酸化中对食管鳞状细胞癌发展的作用。

• 批准号: 22790625
• 负责人: UNO Kaname
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790625/
• 关键词: ヒト食道扁平上皮癌; 酸化ストレス; EGFR; HNE; GSTA4; GSH; 食道扁平上皮癌; 4-HNE

Oxidative stress might participate in the carcinogenesis of human esophageal squamous cell carcinoma (hESCC). 4-hydroxynonenal (HNE)is a major product of membrane lipid peroxidation trapped with glutathione (GSH)and catalyzed by glutathione S-transferases (GSTs). HNE is known to activate epidermal growth factor receptor (EGFR)signaling. This study aimed to elucidate the possible participation of HNE, the GSH/GST system and EGFR signaling in hESCC development. We first demonstrated that the ligand-independent activation of EGFR by the balance between HNE and the intrinsic GSH/GST system might participate in the development of hESCC. These would provide useful clues for cancer prevention and treatment of hESCC.

氧化应激可能参与人食管鳞状细胞癌（hESCC）的癌变。 4-羟基壬烯醛 (HNE) 是谷胱甘肽 (GSH) 捕获并由谷胱甘肽 S-转移酶 (GST) 催化的膜脂过氧化的主要产物。众所周知，HNE 可以激活表皮生长因子受体 (EGFR) 信号传导。本研究旨在阐明 HNE、GSH/GST 系统和 EGFR 信号传导在 hESCC 发育中的可能参与。我们首先证明，HNE 和内在 GSH/GST 系统之间的平衡对 EGFR 的配体依赖性激活可能参与了 hESCC 的发生。这些将为hESCC的癌症预防和治疗提供有用的线索。

项目成果

The balance between 4-Hydroxynonenal and intrinsic Glutathione/Glutathione S-Transferase A4 system may be critical for the Epidermal Growth Factor Receptor phosphorylation of human esophageal squamous cell carcinomas

4-羟基壬烯醛和内在谷胱甘肽/谷胱甘肽 S-转移酶 A4 系统之间的平衡可能对于人食管鳞状细胞癌的表皮生长因子受体磷酸化至关重要

• 发表时间: 2011
• 期刊: Mol Carcinog
• 作者: Uno K;Kato K;Kusaka G;Asano N;Iijima K;Shimosegawa T
• 通讯作者: Shimosegawa T

The direct measurement of non-acid reflux episodes in patients with or without squamous cell carcinoma by 24 hours pH-impedance monitoring

通过 24 小时 pH 阻抗监测直接测量患有或不患有鳞状细胞癌的患者的非酸反流发作

• 发表时间: 2011
• 作者: Uno K;Iijima K;et al
• 通讯作者: et al

The balance between 4-Hydroxynonenal and intrinsic Glutathione/Glutathione S-Transferases A4 system may be critical for the Epidermal Growth Factor Receptor phosphorylation of human esophageal squamous cell carcinomas

4-羟基壬烯醛和内在谷胱甘肽/谷胱甘肽 S-转移酶 A4 系统之间的平衡可能对于人食管鳞状细胞癌的表皮生长因子受体磷酸化至关重要

• 发表时间: 2011
• 期刊: Molecular Carcinogenesis
• 影响因子: 4.6
• 作者: Kaname Uno;et al
• 通讯作者: et al

Direct measurement of gastroesophageal reflux episodes in patients with squamous cell carcinoma by 24-hr pH-impedance monitoring

通过 24 小时 pH 阻抗监测直接测量鳞状细胞癌患者的胃食管反流发作

• 发表时间: 2011
• 期刊: American Journal of Gastroenterology
• 影响因子: 9.8
• 作者: Uno K;et.Al.
• 通讯作者: et.Al.

The direct role of NO in the development of Barrett's esophagus and Barrett's adenocarcinoma

NO 在 Barrett 食管和 Barrett 腺癌发展中的直接作用

• 发表时间: 2011
• 作者: Kusaka G;Uno K;et al
• 通讯作者: et al