Analysis of roles and physiological functions of Intrinsic Cardiac Adrenergic Cell in rodent cardiac transplantation model.

内源性心脏肾上腺素细胞在啮齿动物心脏移植模型中的作用和生理功能分析。

• 批准号: 22790727
• 负责人: TAMURA Yuichi
• 金额: $ 2.58万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790727/
• 关键词: 分子心臓病態学; 組織幹細胞; 心臓移植; 神経提

We identified the Intrinsic Cardiac Adrenergic Cell(ICA cell) are derived from neural crest by analyzing P0-Cre x Floxed-GFP transgenic mice. We found a driving factor for promoting the proliferation and differentiation into ICA cell. And we confirmed the contraction and heart rate of transplanted hearts were affected with the development of ICA cell.

我们通过分析p0-cre x floxed-GFP转基因小鼠来确定内在心脏肾上腺素能细胞（ICA细胞）。我们发现了促进增殖和分化为ICA细胞的驱动因素。我们证实了移植心脏的收缩和心率受到ICA细胞发育的影响。