Efficacy of antiarrhythmic drugs on early arrhythmia recurrences after pulmonary vein isolation for atrial fibrillation

抗心律失常药物对房颤肺静脉隔离术后早期心律失常复发的疗效

• 批准号: 22790735
• 负责人: HAYASHI Meiso
• 金额: $ 2万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790735/
• 关键词: 臨床心血管病態学; 心房細動; 抗不整脈薬; 薬物治療

Atrial tachyarrhythmias commonly recur shortly after radiofrequency catheter ablation (pulmonary vein isolation) for atrial fibrillation (AF). We prospectively examined the efficacy of three-month low-dose flecainide therapy (150 or 100 mg/day) on the recurrences of any atrial tachyarrhythmias during the first three months after AF ablation (primary endpoint). After the ablation, the patients were randomly assigned to the flecainide group (n=62) or to the control group (n=64) receiving no antiarrhythmic drugs. The rates of primary endpoint was 37% and 41% (P=0.76) in the flecainide and control groups, respectively. Long-term arrhythmia recurrence rates were also not different (21% vs. 25%, P=0.54). Short-term low-dose flecainide therapy after AF ablation did not reduce the early and the late arrhythmia recurrences.

心房快速性心律失常通常在射频导管消融（肺静脉隔离）治疗房颤（AF）后不久复发。我们前瞻性研究了3个月低剂量氟卡尼治疗（150或100 mg/天）对房颤消融术后前3个月内任何房性快速性心律失常复发的疗效（主要终点）。消融术后，患者被随机分配到氟卡尼组（n=62）或对照组（n=64），不接受抗肿瘤药物。氟卡尼组和对照组的主要终点发生率分别为37%和41%（P=0.76）。长期心律失常复发率也无差异（21% vs. 25%，P=0.54）。AF消融后短期小剂量氟卡尼治疗不能减少早期和晚期心律失常的复发。

项目成果

Intravenous adenosine reveals arrhythmogenic foci in patients with atrial fibrillation udergoing radiofrequency catheter ablation

静脉注射腺苷可揭示接受射频导管消融术的房颤患者的致心律失常病灶

• 发表时间: 2011
• 作者: Meiso Hayashi;Yasushi Miyauchi;Hiroshige Murata;Meiso Hayashi;Ippei Tsuboi;Meiso Hayashi;Meiso Hayashi;林洋史;Ippei Tsuboi
• 通讯作者: Ippei Tsuboi

Intravenous adenosine quickly reveals arrhythmogenic foci in patients with atrial fibrillation undergoing radiofrequency catheter ablation

静脉注射腺苷可快速揭示接受射频导管消融的心房颤动患者的致心律失常病灶

• 发表时间: 2011
• 作者: Meiso Hayashi;Yasushi Miyauchi;Hiroshige Murata;Meiso Hayashi;Ippei Tsuboi;Meiso Hayashi;Meiso Hayashi;林洋史;Ippei Tsuboi;坪井一平;Ippei Tsuboi;坪井一平;Ippei Tsuboi
• 通讯作者: Ippei Tsuboi

完全ブロックをエンドポイントとした左房線状焼灼を付加した拡大肺静脈隔離の持続性心房細動に対する有効性

扩大肺静脉隔离联合左心房线性消融治疗以完全传导阻滞为终点的持续性心房颤动的疗效

• 发表时间: 2012
• 作者: Meiso Hayashi;Yasushi Miyauchi;Hiroshige Murata;Meiso Hayashi;Ippei Tsuboi;Meiso Hayashi;Meiso Hayashi;林洋史
• 通讯作者: 林洋史

Acalculous cholecystitis: an unexpected complication of catheter ablation of atrial fibrillation resulting from vagus nerve injury

非结石性胆囊炎：迷走神经损伤引起的房颤导管消融术的意外并发症

• 作者: Meiso Hayashi;Yasushi Miyauchi;Hiroshige Murata;Meiso Hayashi;Ippei Tsuboi;Meiso Hayashi;Meiso Hayashi;林洋史;Ippei Tsuboi;坪井一平;Ippei Tsuboi;坪井一平;Ippei Tsuboi;Hiroshi Hayashi;林洋史;坪井一平;Meiso Hayashi;Ippei Tsuboi
• 通讯作者: Ippei Tsuboi

Urgent catheter ablation for sustained ventricular tachyarrhythmias in patients with acute heart failure decompensation

• DOI: 10.1093/europace/eut207
• 发表时间: 2014-01-01
• 期刊: EUROPACE
• 影响因子: 6.1
• 作者: Hayashi, Meiso;Miyauchi, Yasushi;Mizuno, Kyoichi
• 通讯作者: Mizuno, Kyoichi