ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertension
ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertension
批准号:
22790750
负责人:
KOINUMA Daizo
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Bone morphogenetic protein(BMP) signaling is closely related to idiopathic pulmonary hypertension. Using pulmonary arterial smooth muscle cells(PASMCs) and endothelial cells, we determined Smad1/Smad5 binding sites by chromatin immunoprecipitation-sequencing(ChIP-seq). We identified PASMCs-specific novel target gene. We examined and found its role in patho-physiology of pulmonary hypertension by siRNA and its inhibitor.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
TGF-βによる転写制御
TGF-β 的转录调控
DOI:
--
发表时间:
2010
期刊:
医学のあゆみ
影响因子:
--
作者:
[Morikawa M, Koinuma D, Tsutsumi S,Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K, 鯉沼代造]
通讯作者:
鯉沼代造
Mechanism of Smad Signaling Modification by TTF1 in lung Cancer Cells
TTF1在肺癌细胞中修饰Smad信号的机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Aburatani H, Miyazono K]
通讯作者:
Miyazono K
DOI:
10.1093/jb/mvr136
发表时间:
2012-02-01
期刊:
JOURNAL OF BIOCHEMISTRY
影响因子:
2.7
作者:
[Kawata, Mikiko, Koinuma, Daizo, Miyazono, Kohei]
通讯作者:
Miyazono, Kohei
"Cistrome" of the TGF-β-Smad signaling pathway
TGF-β-Smad 信号通路的“Cistrom”
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K., 鯉沼代造]
通讯作者:
鯉沼代造
Characterization of Smad2 and Smad3 binding sites by genome-wide ChIP-chip/ChIP-sequencing analysis
通过全基因组 ChIP 芯片/ChIP 测序分析表征 Smad2 和 Smad3 结合位点
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K., 鯉沼代造, 鯉沼代造]
通讯作者:
鯉沼代造
共 12 条
Cistromic analysis of EMT regulators in breast cancer cells
-
批准号:24501311
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:KOINUMA Daizo
-
依托单位:
Role of lung cancer cells to fibrosis and regulation of TGF-beta signaling by EGF
-
批准号:20790580
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:KOINUMA Daizo
-
依托单位:
海外基金