The role of Paraoxonase-1 in chronic kidney disease and renovascular injury

Paraoxonase-1 在慢性肾脏病和肾血管损伤中的作用

• 批准号: 22790777
• 负责人: ICHIKAWA Kazunobu
• 金额: $ 2.5万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790777/
• 关键词: Paraoxonase-1; 慢性腎臓病; 遺伝子多型; PON1; CKD; 遺伝子多形; SNPs

We performed immunohistochemistry for PON1 in rat 5/6 nephrectomy model. It showed that PON1 expression in vascular endothelium was associated with renovascular injury. Then we examined the association of PON1 genotype (rs662) and prognosis among patients with end-stage renal disease. However, there was no significant difference between survival rate and PON1 genotype, suggesting that PON1 gene was not associated with the risk of cardiovascular disease and prognosis in end-stage renal disease.

我们在大鼠5/6肾切除模型中进行了PON 1的免疫组织化学研究。结果表明，血管内皮细胞PON 1的表达与肾血管损伤有关。然后我们研究了PON 1基因型（rs662）与终末期肾病患者预后的关系。但PON 1基因型与生存率无显著性差异，提示PON 1基因与终末期肾病患者心血管疾病风险及预后无关。

项目成果

Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study

日本普通人群促炎细胞因子基因多态性和蛋白尿：高畑研究

• DOI: 10.1093/ndt/gfr105
• 发表时间: 2011
• 期刊: Nephrol Dial Transplant
• 作者: Mashima Y;Konta T;Kudo K;Suzuki K;Ikeda A;Ichikawa K;Shibata Y;Watanabe T;Tamiya G;Kato T;Kawata S;Kubota I.
• 通讯作者: Kubota I.

透析患者におけるParaoxonase-1遺伝子多型と生命予後に関する検討

对氧磷酶1基因多态性与透析患者生命预后的研究

• 发表时间: 2012
• 作者: 市川一誠;今田恒夫;久保田功;他
• 通讯作者: 他