Studies on action mechanism of protective effects of angiogenesis inhibitor against the diabetic nephropathy.

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The pathological conditions of diabetes originate in a systemic microangiopathy. In this study, we investigated the mechanisms of action by which angiogenesis inhibitor angiostatin protects the diabetic nephropathy. Angiostatin attenuated the endothelial dysfunction through the inhibition of nuclear translocation of NF-κB induced by inflammatory cytokine. We showed the binding between angiostatin and its novel target receptor. It is expected that these observations contribute to the therapeutic effects of angiostatin to the diabetic nephropathy.