The role of Complement Pathways in IgA nephropathy

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We researched complement pathway in IgA nephropathy model mouse “grouped ddY mouse(gddY)”. We observed that polymeric IgA and IgA-IgG immune complex regulate severity of IgA nephropathy by the activation of complement pathway in gddY. The other hand, gddY have more amount of aberrantly glycosylated IgA than Balb/c. From this finding, we think that the degree of glycosylation of IgA influence the formation of polymeric IgA and IgA-IgG immune complex. Therefore, aberrantly glycosylated IgA may influence the formation of macromolecular IgA including IgA-IgG immune complexes and subsequent complement activation, leading to full progression of IgAN.