The role of Complement Pathways in IgA nephropathy

补体途径在 IgA 肾病中的作用

• 批准号: 22790804
• 负责人: TANAKA Yuichi
• 金额: $ 2.5万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790804/
• 关键词: IgA 腎症; 補体; レクチン経路; 骨髄移植; MBL; IgA腎症; Mannose-binding lectin; C57Bl/6; Bald/c; grouped ddY; 放射線感受性; Lectin Pathway; Mannose-Binding-Lectin (MBL); grouped ddYマウス; 免疫複合体; 放射線; 補体lectin pathway; classical pathway; Clq; Alternative Pathway

We researched complement pathway in IgA nephropathy model mouse “grouped ddY mouse(gddY)”. We observed that polymeric IgA and IgA-IgG immune complex regulate severity of IgA nephropathy by the activation of complement pathway in gddY. The other hand, gddY have more amount of aberrantly glycosylated IgA than Balb/c. From this finding, we think that the degree of glycosylation of IgA influence the formation of polymeric IgA and IgA-IgG immune complex. Therefore, aberrantly glycosylated IgA may influence the formation of macromolecular IgA including IgA-IgG immune complexes and subsequent complement activation, leading to full progression of IgAN.

我们研究了IgA肾病模型小鼠“分组ddY小鼠（gddY）”的补体通路。我们观察到聚合IgA和IgA- igg免疫复合物通过激活补体途径调节gddY中IgA肾病的严重程度。另一方面，gddY比Balb/c有更多的异常糖基化IgA。由此，我们认为IgA的糖基化程度影响聚合IgA和IgA- igg免疫复合物的形成。因此，异常的IgA糖基化可能影响包括IgA- igg免疫复合物在内的大分子IgA的形成和随后的补体活化，导致IgAN的完全进展。

项目成果

IgA腎症における捕体系関与の検討～IgA腎症自然発症モデルを用いて～

检查捕获系统在 IgA 肾病中的参与 ~ 使用自发性 IgA 肾病模型 ~

• 发表时间: 2011
• 作者: Hashimoto A;Suzuki Y;Suzuki H;Ohsawa I;Brown R;Hall S;Tanaka Y;Novak J;Ohi H;Tomino Y.;橋本梓;橋本梓
• 通讯作者: 橋本梓

Both Lectin and Classical Complement Pathways Determine the Severity of Murine IgA Nephropathy

凝集素和经典补体途径共同决定小鼠 IgA 肾病的严重程度

• 发表时间: 2011
• 作者: Hashimoto A;Suzuki Y;Suzuki H;Ohsawa I;Brown R;Hall S;Tanaka Y;Novak J;Ohi H;Tomino Y.;橋本梓
• 通讯作者: 橋本梓

Determination of Severity of Murine IgA Nephropathy by Glomerular Complement Activation by Aberrantly Glycosylated IgA and Immune Complexes

• DOI: 10.1016/j.ajpath.2012.06.038
• 发表时间: 2012-10-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Hashimoto, Azusa;Suzuki, Yusuke;Tomino, Yasuhiko
• 通讯作者: Tomino, Yasuhiko