Study to control metastasis of HNSCC by targeting molecular mechanisms leading to epithelial-mesenchymal transition (EMT)

EMT （epithelial to mesenchymal transition，上皮向间质转化）与癌转移过程密切相关，我们的研究结果如下：1)E-cadherin下调和SIP1过表达被认为是舌鳞癌颈部淋巴结转移的预测因素。2) Ang2除诱导EMT外，还通过抑制细胞凋亡提高细胞存活能力，从而增强乳腺癌细胞的转移能力。3)选择性抑制cox - 2，其抗肿瘤作用包括抑制EMT。

Our study of EMT (epithelial to mesenchymal transition), which is closely involved in a process of cancer metastasis, led to the following results:1) Downregulation of E-cadherin and overexpression of SIP1 were considered to be predictive of cervical lymph node metastasis of tongue squamous cell carcinoma.2) Ang2 was shown to enhance metastatic ability of breast cancer cells by promoting cell survival ability via suppression of apoptosis, in addition to induction of EMT.3) Selective Cox2-inhibition was revealed to include suppression of EMT in its anti-tumor effect.