Study to control metastasis of HNSCC by targeting molecular mechanisms leading to epithelial-mesenchymal transition (EMT)

我们对与肿瘤转移过程密切相关的上皮向间充质转化(EMT)的研究得出以下结果：1)E-钙粘素表达下调和SIP1过度表达被认为是舌鳞状细胞癌颈淋巴转移的预测因素。2)Ang2被证明除了诱导EMT外，还通过抑制细胞凋亡来促进乳腺癌细胞的转移能力。3)选择性COX2抑制被发现在其抗肿瘤作用中包括对EMT的抑制。

Our study of EMT (epithelial to mesenchymal transition), which is closely involved in a process of cancer metastasis, led to the following results:1) Downregulation of E-cadherin and overexpression of SIP1 were considered to be predictive of cervical lymph node metastasis of tongue squamous cell carcinoma.2) Ang2 was shown to enhance metastatic ability of breast cancer cells by promoting cell survival ability via suppression of apoptosis, in addition to induction of EMT.3) Selective Cox2-inhibition was revealed to include suppression of EMT in its anti-tumor effect.