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The effect of adipocytokines on retinal circulation in patients with type 2 diabetes

The effect of adipocytokines on retinal circulation in patients with type 2 diabetes
脂肪细胞因子对2型糖尿病患者视网膜循环的影响
批准号:
22591961
负责人:
NAGAOKA Taiji
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
1) Basic Research We have reported that fenofibrate and cilostazol cause vasodilation and that homocystein impairs endothelial function of isolated porcine retinal arterioles. In addition, we also have reported that retinal endothelium, by releasing vasoactive substances, contributes to RBF regulation during acute severe elevation of systemic blood pressure in in vivo cat model.2) Clinical Study We have found that retinal blood flow was decreased in patients with type 2 diabetes and renal dysfunction and that systemic endothelial function was impaired in patients with branch retinal vein occlusion.
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DOI: 10.1167/iovs.11-8841
发表时间: 2012-05-01
期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子: 4.4
作者: [Omae, Tsuneaki, Nagaoka, Taiji, Yoshida, Akitoshi]
通讯作者: Yoshida, Akitoshi
Yoshida A. Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: Role of endothelium-derived factors
Yoshida A. 猫视网膜动脉对全身血压急性严重升高的反应:内皮衍生因子的作用
DOI: --
发表时间:
期刊: Exp Eye Res
影响因子: 3.4
作者: [Nakabayashi S, Nagaoka T^*, Tani T, Sogawa K, Hein TW, Kuo L, Yoshida A]
通讯作者: Yoshida A
DOI: 10.1167/iovs.12-11082
发表时间: 2013-03-01
期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子: 4.4
作者: [Omae, Tsuneaki, Nagaoka, Taiji, Yoshida, Akitoshi]
通讯作者: Yoshida, Akitoshi
Dilation of porcine retinal arterioles to cilostazol: roles of eNOS phosphorylation via cAMP/protein kinase A and AMP-activated protein kinase and potassium channel
猪视网膜小动脉对西洛他唑的扩张:eNOS 磷酸化通过 cAMP/蛋白激酶 A 和 AMP 激活的蛋白激酶和钾通道的作用
DOI: --
发表时间: 2013
期刊: Invest Ophthalmol Vis Sci
影响因子: --
作者: [Tanano I, Nagaoka T^*, Omae T, Ishibazawa A, Kamiya T, Ono S, Yoshida A]
通讯作者: Yoshida A
18
    Time course of retinal blood flow in diabetic pigs
    • 批准号:
      17K11473
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2017
    • 负责人:
      NAGAOKA Taiji
    • 依托单位:
    Elucidation of regulatory mechanism of neurovascular coupling interaction in retinal circulation and clinical application for early diagnosis of diabetic retinopathy
    • 批准号:
      25293352
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.82万
    • 财政年份:
      2013
    • 负责人:
      NAGAOKA Taiji
    • 依托单位:
    The role of gas molecules in ther egulation of retinal blood flow
    • 批准号:
      25670724
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2013
    • 负责人:
      NAGAOKA Taiji
    • 依托单位:
    Translational research of ocular circulation for new treatment of diabetic retinopathy
    • 批准号:
      19689035
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $8.65万
    • 财政年份:
      2007
    • 负责人:
      NAGAOKA Taiji
    • 依托单位:
    海外基金