Investigation of importance of existence of the primary cilia involved in viability of the corneal endothelium.

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We examined corneal endothelia of donor eyes which were provided by the U.S. Eye-bank and were used for corneal transplantation, and we found that about 5% of dead cells were present in the endothelial cells. It was considered that the increase of dead cells during storage might cause decrease of the number of the endothelial cells aftercorneal transplantation. In addition, when the rabbit cornea was stored at 4 ℃ in the corneal storage media, primary cilia in the corneal endothelial cells were disappeared, and they were reappeared after recovery culture at 37 ℃. The presence of primary cilia was thought to have some kind of relationship to viability of corneal endothelium.