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Investigation of importance of existence of the primary cilia involved in viability of the corneal endothelium.

研究初级纤毛的存在对角膜内皮活力的重要性。

基本信息

批准号：
22591947
负责人：
TANIOKA Hidetoshi
金额：
$ 2.91万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

We examined corneal endothelia of donor eyes which were provided by the U.S. Eye-bank and were used for corneal transplantation, and we found that about 5% of dead cells were present in the endothelial cells. It was considered that the increase of dead cells during storage might cause decrease of the number of the endothelial cells aftercorneal transplantation. In addition, when the rabbit cornea was stored at 4 ℃ in the corneal storage media, primary cilia in the corneal endothelial cells were disappeared, and they were reappeared after recovery culture at 37 ℃. The presence of primary cilia was thought to have some kind of relationship to viability of corneal endothelium.

我们检查了由美国眼库提供的用于角膜移植的供体眼的角膜内皮，我们发现约5%的死细胞存在于内皮细胞中。认为角膜移植后内皮细胞数量减少可能与保存过程中死亡细胞的增加有关。此外，兔角膜在4 ℃保存液中保存时，角膜内皮细胞中的初级纤毛消失，在37 ℃恢复培养后重新出现。原纤毛的存在被认为与角膜内皮细胞的活力有某种关系。