Analysis of mechanisms of the inflammation regulated by receptors of prostaglandins in ocular surface epithelial cells

本研究利用实验性变态反应性结膜炎小鼠模型，发现PGE2受体的一个亚型EP3主要在眼表上皮细胞中表达，它能抑制眼表炎症，并可能有助于眼表的动态平衡。此外，我们还发现EP3主要在人的眼表上皮细胞中表达，而在Stevens-Johnson综合征和瘢痕性眼类天疱疮等人眼表炎性疾病的结膜上皮细胞中，EP3的表达明显下调。我们的发现提示PG受体可能在人类眼表疾病中起作用。

In this study, using experimental allergic conjunctivitis mouse model, we have showed that EP3, a subtype of PGE2 receptors, was dominantly expressed in ocular surface epithelium, and that it could suppress the ocular surface inflammation and might contribute the homeostasis of ocular surface. Moreover, we have also showed that EP3 was dominantly expressed in human ocular surface epithelium, and that in the conjunctival epithelium of human ocular surface inflammatory disease such as Stevens-Johnson syndrome and cicatricial ocular pemphigoid, the expression of EP3 were remarkably down-regulated. Our findings suggest that PG receptors might contribute in human ocular surface diseases.