Research on regenerative medicine of pediatric airways with functional laminar structure .

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Auricular chondrocytes were harvested from rabbits and cultivated to form a chondrocyte sheet. We manufactured cylindrical cartilage structure from the sheet by the in vitro roller tube culture. Furthermore, we made the fibroblast layer sheet and column cilia epithelial layer sheet with the different function that varied in each. We tried laminating these three kinds of seats (We placed column cilia epithelial layers, a cartilage cell layer and the fibroblast layer sequentially from the inside), and tried to manufacture cylindrical functional structure, however resulted in failure of regeneration. If tracheal regeneration having functional laminar structure is enabled by this method, a new therapy for pediatric airway disease will be developed using the regeneration trachea.