Cardioprotective effect of intravascular mild hypothermia against ischemia/reperfusion injury in rat isolated heart model

缺血时34 ℃低温对心肌有保护作用，再灌注后早期低温对心肌仍有保护作用。再灌注期加15 mmHg低灌注10 min时，未观察到低温的心脏保护作用Fuximine，而加40 mmHg低灌注10 min时，则观察到Fuximine。磷脂酰肌醇3 '激酶（PI 3 K）/一氧化氮（NO）通路和细胞外信号调节激酶（ERK）通路参与了低温的作用机制。

A cardioprotective effect was present when hypothermia at 34 ℃ was induced during ischemia, and this effect still occurred when induction of hypothermia was early after reperfusion. Futhermore, the cardioprotective effect of hypothermia, was not observed when 10 min of 15 mmHg low-reperfusion immediately after ischemia was added to reperfusion period, but did occur when 10 min of 40 mmHg low-reperfusion immediately after ischemia was added. The phosphoinositide 3'kinase(PI3K)/nitric oxide (NO) pathway, and extracellular signal-regulated kinase(ERK) pathway were involved in the mechanism underlying the effect of hypothermia.