tudy of therapeutic effect of sodium nitrite on crush syndrome

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We developed crush syndrome (CS) rat model to evaluate the therapeutic effect of nitrite on crush syndrome. Intraperitoneal single injection of nitrite improved survival rate of this CS model from 25% to 64%, furthermore combined therapy of continuous infusion of nitrite with conventional therapies including massive fluid infusion and correction of acidosis resulted in 100% survival rate. This might be due to the tissue protective effect of nitrite-derived nitric oxide (NO) against ischemia/reperfusion injury. A 100% survival rate was also achieved by the treatment of the CS rat with single injection of dexamethasone through a mechanism involving NO production in the injured skeletal muscle．These results provide not only a new protective mechanism against ischemia/reperfusion injury in this syndrome, but also a simple and promising drug therapy especially useful in the field of disasters