tudy of therapeutic effect of sodium nitrite on crush syndrome

建立挤压综合征大鼠模型，评价亚硝酸盐对挤压综合征的治疗作用。腹腔单次注射亚硝酸盐可使CS模型存活率从25%提高到64%，再结合常规治疗方法（大量输液、纠正酸中毒）持续输注亚硝酸盐，使CS模型存活率达到100%。这可能是由于亚硝酸盐衍生的一氧化氮（NO）对缺血/再灌注损伤的组织保护作用。单次注射地塞米松治疗CS大鼠的存活率也达到100%，其机制与损伤骨骼肌产生NO有关。这些结果不仅为该综合征提供了一种新的抗缺血再灌注损伤的保护机制，而且在灾害领域提供了一种简单而有前景的药物治疗方法

We developed crush syndrome (CS) rat model to evaluate the therapeutic effect of nitrite on crush syndrome. Intraperitoneal single injection of nitrite improved survival rate of this CS model from 25% to 64%, furthermore combined therapy of continuous infusion of nitrite with conventional therapies including massive fluid infusion and correction of acidosis resulted in 100% survival rate. This might be due to the tissue protective effect of nitrite-derived nitric oxide (NO) against ischemia/reperfusion injury. A 100% survival rate was also achieved by the treatment of the CS rat with single injection of dexamethasone through a mechanism involving NO production in the injured skeletal muscle．These results provide not only a new protective mechanism against ischemia/reperfusion injury in this syndrome, but also a simple and promising drug therapy especially useful in the field of disasters