A possible role of glucose transporters and monocarboxylate transporters in osteocytes during changes of extracellular milieus

在小鼠下颌骨的牙槽骨中，骨重建后新形成的板层骨的结构与老骨有明显的不同。鬼臼乙素染色观察到新骨与老骨之间未见骨小管网络连接。新生骨细胞HIF-1α、HIF-2α、GLUT_3和MCT2呈阳性表达，而新生骨中未见表达。我们的结论是，骨细胞通过表达HIF、GLUT和MCTs在恶劣的环境中生存。

In alveolar bone of mouse mandibular bone, the structure of lamellar bone newly formed after bone remodeling was clearly different from that of older bone. It was observed by phalloidin stainingthat the network of bone canaliculi was not connected between the new bone and older bone. Osteocytes in the old bone showed positive staining of HIF-1α, HIF-2α, GLUT3 and MCT2, whereas those in the new bone was not stained. We conclude that osteocytes survive in a severe milieus through expression of HIFs, GLUTs and MCTs.